CEFMAST DC

COMPOSITION

A syringe (3 g) contains

Active substance

Cefquinome 150 mg (as sulphate)                                 

TARGET SPECIES

Cattle (cows in dry period)

INDICATIONS

In cows in dry period, for the treatment of subclinical mastitis and the prevention of new bacterial infections occurring during the dry period, caused by microorganisms susceptible to Cefquinome. : Staphylococcus aureus, coagulase-negative staphylococci. Streptococci (including S. agalactiae, S. Dysgalactiae and S. uberis).

CONTRAINDICATIONS

Do not use in animals with known hypersensitivity to cephalosporins or other beta-lactam antibiotics. Do not use in cows with clinical mastitis.

ADVERSE REACTIONS

None known.

DOSAGE FOR EACH SPECIES, METHOD AND ROUTE(S) OF ADMINISTRATION

Single intramammary administration. 

Cefquinome 150 mg, equivalent to a syringe, should be carefully introduced every quarter, immediately after the last milking. 

WARNINGS/ADVICE ON CORRECT ADMINISTRATION

Prior to treatment, the udder should be milked completely. The nipple and its orifice should be carefully cleaned and disinfected with disposable napkins. Steps must be taken not to contaminate the injector nozzle. Carefully insert 5 mm of the total length of the nozzle and inject the contents of a syringe every quarter. The product is dispersed by light massage of the nipple and the udder. The syringe should only be used once.

WITHDRAWAL PERIOD(S)

Meat and offal: 0 days.

Milk: 12 hours after calving (after the standard dry period of 5-9 weeks). If the dry period was shorter than 6 weeks, it is recommended to test the milk for residues prior to delivery.

SHELF LIFE

Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Shelf-life after first opening the immediate packaging: 28 days.

SPECIAL PRECAUTIONS FOR STORAGE

Keep out of reach of children. Do not store above 25 °C. Keep in a dry place.

SPECIAL WARNING(S)

None.

SPECIAL PRECAUTIONS FOR USE IN ANIMALS

This product should be used with regard to susceptibility testing of isolated bacteria from animals. If this is not possible, local epidemiological information (regional or from the farm) should be taken into account as regards the target bacteria’s susceptibility. Do not use napkins on nipples with injuries. In the case of erroneous use during the lactation period, the milk will be removed for 35 days. Efficacy was established only for the pathogens mentioned in section 4.2 of the SmPC. As a result, severe acute mastitis produced by other pathogens, especially Pseudomonas aeruginosa, may occur after the dry period. Hygiene maintenance practices must be strictly observed to reduce this risk; the cows must be kept in hygienic stables, away from the milking area and regularly checked for several days after the dry period.

SPECIAL PRECAUTIONS TO BE TAKEN BY THE PERSON ADMINISTERING THE PRODUCT:

Penicillins and cephalosporins may produce hypersensitivity (allergy) reactions after self-injection, inhalation, ingestion or skin contact. Penicillin hypersensitivity may be associated with cross-sensitivity to cephalosporins and vice versa. Occasionally, the allergic reactions to these substances can be serious. Do not handle this product if you know you are a person exhibiting sensitivity to it or have been warned not to handle such preparations. Handle this product with great care to prevent exposure and take all precautions. Use waterproof gloves when handling and administering the product. Wash the skin exposed after use. If symptoms occur from exposure to this product, such as rash, you should immediately see a doctor and present this warning. Swelling of the face, lips or eyes or difficulty breathing are more serious symptoms and require immediate medical attention. Wash hands after using napkins and wear protective gloves in case of known or suspected irritation to isopropyl alcohol. Avoid contact with eyes because isopropyl alcohol may cause eye irritation.

USE DURING PREGNANCY AND LACTATION 

Reproductive toxicity in cows (including teratogenicity) has not been demonstrated. Laboratory studies in rats and rabbits have not shown teratogenic, foetotoxic or maternotoxic effects. Cefamast DC is intended for use during gestation. No adverse effects on foetuses were observed in clinical trials.

Do not use during lactation.

INTERACTION WITH OTHER MEDICINAL PRODUCTS AND OTHER FORMS OF INTERACTION

The neutralising effect of bacteriostatic pharmaceutical substances (macrolides, sulphonamides and tetracyclines) on the bactericidal effect of cefquinome has not been evaluated yet. Thus, there is no information on the safety and efficacy of this type of association.

INCOMPATIBILITIES

None known.

SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCTS OR WASTE MATERIALS, IF ANY.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. Medicines should not be disposed of via waste water or household waste.

PRESENTATION/PACKAGE

White low-density polyethylene syringes.