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For the treatment of subclinical mastitis at drying off and the prevention of new bacterial infections of the udder during the dry period in the dairy cow caused by the following cefquinome susceptible organisms: Streptococcus uberis, Streptococcus dysgalactiae, Streptococcus agalactiae, Staphylococcus aureus, coagulase negative staphylococci.
Each syringe of 3 g contains:
Cefquinome 150 mg (equivalent to 178.57 mg cefquinoma sulfate)
Do not use in cows with clinical mastitis.
Do not use in cases of known hypersensitivity to cephalosporin antibiotics or other β-lactam antibiotics, or to any of the excipients.
None known.
Intramammary use. Single intramammary administration.
150 mg cefquinome, i.e. the content of one intramammary syringe should be instilled gently into the teat of each quarter, immediately after the last milking.
Before instillation, the udder should be milked out completely and the teat and its orifice should be thoroughly cleaned and disinfected. Care should be taken to avoid contamination of the injector nozzle. Gently insert either about 5mm or the total length of the nozzle and instill the content of one syringe into each quarter. Disperse the product by gentle massage of the teat and udder.
The intramammary syringe must only be used once.
Meat and offal: zero days.
Milk: 12 hours after calving (when dry period is 5 – 9 weeks). If dry period was less than 6 weeks, checking the residues in milk is recommended.
Keep out of the sight and reach of children.
Do not store above 25oC.
Store in a dry place.
Shelf-life of the veterinary medicinal product as packaged for sale: 2 years.
Special precautions for use
Special precautions for use in animals
In cows that may have subclinical mastitis, the product may be used following administration of a suitable dry cow antibiotic treatment to the infected quarter. In clinical trials, the compatibility of the product has only been shown with a cloxacillin containing dry cow preparation.
As with all dry cow intramammary treatments, it is good practice to observe dry cows regularly for signs of clinical mastitis. If a sealed quarter develops clinical mastitis the affected quarter should be stripped out manually before appropriate antibiotic therapy is instituted. To reduce the risk of contamination, do not immerse syringes in water. Use syringe only once.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross sensitivity to cephalosporin and vice versa. Allergic reactions to these substances may occasionally be serious. Do not handle this product if you know you are sensitized to penicillins or cephalosporins, or if you have been advised not to work with such preparations. Handle this product with great care to avoid exposure. Use impervious gloves when handling and administering the product. Wash exposed skin after use.
If you develop symptoms following exposure, such as skin rash, you should seek medical advice immediately and show the package leaflet or the label to the physician. Swelling of the face, lips and eyes or difficulty in breathing are more serious symptoms and require urgent medical attention. Persons developing a reaction after contact with the product should avoid handling the product (and other cephalosporin and penicillin containing products) in future.
Wash hands after using the product.
Pregnancy and lactation
There is no evidence of reproductive toxicity (incl. teratogenicity) in cattle. Laboratory studies in rats and rabbits have not shown any teratogenic, foetotoxic or maternotoxic effects. Can be used during pregnancy. No adverse effects on fetuses were observed in clinical trials.
Do not use during lactation.
Interactions with other medicinal products and other forms of interaction
The neutralizing effect of bacteriostatic acting pharmaceuticals (macrolides, sulfonamides and tetracyclines) on bactericidal effect of cefquinome has not been evaluated yet. Therefore, there is no information about the safety and efficacy of this kind of association.
Overdose (symptoms, emergency procedures, antidotes), if necessary
No symptoms expected.
Medicines should not be disposed of via wastewater or household waste. Ask your veterinary surgeon how to dispose of medicines no longer required. These measures should help to protect the environment.
Low-density polyethylene syringe with a cap sealed nozzle, containing 3 g of product.
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