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Neocen 40% is indicated in pigs and broilers in the treatment and metaphylaxis of colibacillosis caused by neomycin sulphate-sensitive strains of Escherichia coli.
Neomycin sulphate 400 mg/g
Do not use in known cases of hypersensitivity to the active substance or to any of the excipients.
The most common reactions are edema, pruritus and conjunctival erythema.
Hypersensitivity reactions including anaphylaxis have been reported very rarely.
Neocen 40% will be administered orally in drinking water, as fallows:
Pigs: a dose of 20-40 mg active substance per kg body weight per day, corresponding to 50-100 mg Neocen 40% per kg body weight per day, for 5 to 8 consecutive days.
Broilers: a dose of 20 mg active substance per kg body weight per day, corresponding to 50 mg Neocen 40% per kg body weight per day, for 7 consecutive days.
The amount of Neocen 40% (CN) will be calculated based on Total Body Weight (TBW) of the herd to be treated and the Total Water Consumption (TWC) of the herd in 24 hours using the formula:
X = dose (mg)/ kg body weight.
400 = mg de neomycin sulphate/1 g Neocen 40% powder
The medicated water should be the only source of drinking water, throughout the treatment period.
The product must be well diluted in drinking water to disperse uniform as much as possible.
The intake of medicated water depends on the clinical condition of the animals.
To ensure a correct dosage, body weight should be determined as accurately as possible to avoid underdosing.
Medicated water must be renewed every 24 hours.
Meat and offal:
Pigs: 7 days.
Broilers: 5 days.
Do not store above 25 °C. Do not refrigerate or freeze. Store in the original package. Store in a dry place. Protect from direct sunlight.
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the immediate packaging: 28 days.
Shelf life after reconstitution into drinking water: 24 h.
Special precautions for use in animals
Use of the veterinary medicinal product should be based on susceptibility testing of the bacteria isolated from the animal.
If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria. Use of the veterinary medicinal product deviating from the instructions given in the SPC may increase the prevalence of resistant bacteria to neomycin.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Handling a product of this nature can generate dust particles in the air, in which case overexposure to neomycin may cause eye and skin irritation and respiratory tract irritation if inhaled.
Special precaution measures should be taken during reconstitution of the product in drinking water.
Use personal protective equipment consisting of gloves, mask, goggles and protective clothing while handling the product. In case of eye contact, rinse the affected area with plenty of water.
Do not smoke, eat or drink while handling this product.
Use during pregnancy, lactation or lay
Do not use in pregnant or lactating sows.
Interaction with other medicinal products and other forms of interaction
Interactions with sulfonamides and vitamin B complex are known.
No local procaine-type anesthetics are used during treatment with neomycin. The effects are antagonistic.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Due to the low absorption, overdose following oral administration of neomycin is unlikely to occur. However, prolonged administration may lead to elevated levels of neomycin which may result in neurotoxicity, ototoxicity and / or nephrotoxicity.
Major incompatibilities
Neomycin sulfate should not be used with streptomycin, kanamycin, gentamicin, colistin because they increase the toxicity of neomycin over the kidneys.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements. Medicines should not be disposed of via wastewater or household waste.
Laminated foil bags (PET) / Low-density polyethylene of 50 g, 100 g, 1 kg and 5 kg.
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